Cell therapy for Parkinson's disease: what next?
Identifieur interne : 000A76 ( Main/Exploration ); précédent : 000A75; suivant : 000A77Cell therapy for Parkinson's disease: what next?
Auteurs : Anders Bjorklund [Suède] ; Jeffrey H. KordowerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- MESH :
- geographic : United States.
- methods : Cell Transplantation, Cell- and Tissue-Based Therapy.
- therapy : Parkinson Disease.
- Animals, Clinical Trials as Topic, Humans, National Institutes of Health (U.S.).
Abstract
The idea to use transplants of dopamine-producing cells to substitute for the lost midbrain dopamine neurons in Parkinson's disease (PD) goes back to the 1970s. In this review we give an overview of the history of cell transplantation in animal models of PD, and summarize the experience gained from the open-label and placebo-controlled clinical trials performed so far using intrastriatal transplants of human fetal dopamine neuroblasts. Further development of this therapeutic approach face numerous challenges, for example in the development of protocols that allow generation of fully functional and safe midbrain dopamine neurons from stem cells. Based on recent promising advancements, efforts are now being made to develop standardized and efficient protocols, and adapt these protocols to good laboratory practice (GLP)/good manufacturing practice (GMP) conditions, to move this technology closer to clinical translation.
DOI: 10.1002/mds.25343
PubMed: 23390097
Affiliations:
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Le document en format XML
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